Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation.

Uranium accumulation in the kidneys and bones following internal contamination results in severe damage, emphasizing the pressing need for the discovery of actinide decorporation agents with efficient removal of uranium and low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic acid, is investigated as a potential uranium decorporation ligand. CD demonstrates markedly lower cytotoxicity than that of diethylenetriaminepentaacetic acid (DTPA), an actinide decorporation agent approved by the FDA, and effectively removes approximately 44.5% of uranyl from NRK-52E cells. More importantly, the results of the prompt administration of the CD solution remove 48.2 and 27.3% of uranyl from the kidneys and femurs of mice, respectively. Assessments of serum renal function reveal the potential of CD to ameliorate uranyl-induced renal injury. Furthermore, the single crystal of CD and uranyl compound (C9H7O2)2·UO2 (denoted as UO2-CD) reveals the formation of uranyl dimers as secondary building units. Thermodynamic analysis of the solution shows that CD coordinates with uranyl to form a 2:1 molar ratio complex at a physiological pH of 7.4. Density functional theory (DFT) calculations further show that CD exhibits a significant 7-fold heightened affinity for uranyl binding in comparison to DTPA.

Risk factors for pulmonary embolism in patients with COVID-19: a systemic review and meta-analysis.

PURPOSE: To detect the risk factors for pulmonary embolism (PE) in patients with COVID-19. METHODS: Studies were searched for in PubMed, Cochrane Library, Web of Science, and EMBASE. Two authors independently screened articles and extracted data. The data were pooled by meta-analysis and three subgroup analyses were performed. RESULTS: Of the 2210 articles identified, 27 studies were included. Pooled analysis suggested that males (odds ratio (OR) 1.49, 95% confidence interval (CI) 1.26-1.75, P = 0.000), obesity (OR 1.37, 95% CI 1.03-1.82, P = 0.033), mechanical ventilation (OR 3.34, 95% CI 1.90-5.86, P = 0.000), severe parenchymal abnormalities (OR 1.92, 95% CI 1.43-2.58, P = 0.000), ICU admission (OR 2.44, 95% CI 1.48-4.03, P = 0.000), and elevated D-dimer and white blood cell values (at two time points: hospital admission or closest to computed tomography pulmonary angiography) (P = 0.000) correlated with a risk for PE occurrence in COVID-19 patients. However, age and common comorbidities had no association with PE occurrence. Computed tomography pulmonary angiography, unclear-ratio/low-ratio, and hospitalization subgroups had consistent risk factors with all studies; however, other subgroups had fewer risk factors for PE. CONCLUSIONS: Risk factors for PE in COVID-19 were different from the classic risk factors for PE and are likely to differ in diverse study populations.

Dynamic biomechanical effect of lower body positive pressure treadmill training for hemiplegic gait rehabilitation after stroke: A case report.

BACKGROUND: Lower body positive pressure (LBPP) treadmill has potential applications for improving the gait of patients after stroke, but the related mechanism remains unclear. CASE SUMMARY: A 62-year-old male patient suffered from ischemic stroke with hemiplegic gait. He was referred to our hospital because of a complaint of left limb weakness for 2 years. The LBPP training was performed one session per day and six times per week for 2 wk. The dynamic plantar pressure analysis was taken every 2 d. Meanwhile, three-digital gait analysis and synchronous electromyography as well as clinical assessments were taken before and after LBPP intervention and at the 4-wk follow-up. During LBPP training, our patient not only improved his lower limb muscle strength and walking speed, but more importantly, the symmetry index of various biomechanical indicators improved. Moreover, the patient's planter pressure transferring from the heel area to toe area among the LBPP training process and the symmetry of lower body biomechanical parameters improved. CONCLUSION: In this study, we documented a dynamic improvement of gait performance in a stroke patient under LBPP training, which included lower limb muscle strength, walking speed, and symmetry of lower limb biomechanics. Our study provides some crucial clues about the potential dynamic mechanism for LBPP training on gait and balance improvement, which is related to rebuilding foot pressure distribution and remodeling symmetry of biomechanics of the lower limb.

Current Application of Digital Diagnosing Systems for Retinopathy of Prematurity.

BACKGROUND AND OBJECTIVE: Retinopathy of prematurity (ROP), a proliferative vascular eye disease, is one of the leading causes of blindness in childhood and prevails in premature infants with low-birth-weight. The recent progress in digital image analysis offers novel strategies for ROP diagnosis. This paper provides a comprehensive review on the development of digital diagnosing systems for ROP to software researchers. It may also be adopted as a guide to ophthalmologists for selecting the most suitable diagnostic software in the clinical setting, particularly for the remote ophthalmic support. METHODS: We review the latest literatures concerning the application of digital diagnosing systems for ROP. The diagnosing systems are analyzed and categorized. Articles published between 1998 and 2020 were screened with the two searching engines Pubmed and Google Scholar. RESULTS: Telemedicine is a method of remote image interpretation that can provide medical service to remote regions, and yet requires training to local operators. On the basis of image collection in telemedicine, computer-based image analytical systems for ROP were later developed. So far, the aforementioned systems have been mainly developed by virtue of classic machine learning, deep learning (DL) and multiple machine learning. During the past two decades, various computer-aided systems for ROP based on classic machine learning (e.g. RISA, ROPtool, CAIER) became available and have achieved satisfactory performance. Further, automated systems for ROP diagnosis based on DL are developed for clinical applications and exhibit high accuracy. Moreover, multiple instance learning is another method to establish an automated system for ROP detection besides DL, which, however, warrants further investigation in future. CONCLUSION: At present, the incorporation of computer-based image analysis with telemedicine potentially enables the detection, supervision and in-time treatment of ROP for the preterm babies.

Quantitative analysis of vowel production in cerebral palsy children with dysarthria.

OBJECTIVE: The present study aimed to identify certain acoustic parameters for speech evaluation in cerebral palsy children with dysarthria. METHODS: The subject included 30 native Mandarin-Speaking children with cerebral palsy, who were 5-15 years old, and 13 healthy children in a similar age range. Each subject was recorded while producing a list of 12 Mandarin words, which included three syllables ('ba', 'bi' and 'du'), in all four Mandarin tones. The formants (F1 and F2) of monophthong vowels /a, i, u/ were extracted from each vowel token. Based on F1 and F2, the vowel acoustic indexes VSA, VAI and FCR were calculated and analyzed. RESULTS: Compared with the control group, the cerebral palsy group had significantly low F1 and F2 in vowel /a/ (P < 0.05), and F2 in vowel /i/ (P < 0.05), while F1 and F2 in vowel /u/ and F1 in vowel /i/ had no significant difference. Between the healthy group and cerebral palsy group, the differences in VSA, VAI and FCR were all statistically significant. CONCLUSION: Children with cerebral palsy have reduced vowel space and speech articulation. The significant difference in vowel acoustic indexes (VSA, VAI and FCR) among the two groups revealed that the three indexes were sensitive to the variation of the vowels production in children with cerebral palsy, and that these may be used as an evaluation method of speech intelligibility caused by impaired vowel pronunciation in children with cerebral palsy, and the effect of rehabilitation therapy.

Acoustic properties of vowel production in Mandarin-speaking patients with post-stroke dysarthria.

This study investigated the acoustic features of vowel production in Mandarin-speaking patients with post-stroke dysarthria (PSD). The subjects included 31 native Mandarin-speaking patients with PSD (age: 25-83 years old) and 38 neurologically normal adults in a similar age range (age: 21-76 years old). Each subject was recorded producing a list of Mandarin monosyllables that included six monophthong vowels (i.e., /a, i, u, ɤ, y, o/) embedded in the /CV/ context. The patients' speech samples were evaluated by two native Mandarin speakers. The evaluation scores were then used to classify all patients into two levels of severity: mild or moderate-to-severe. Formants (F1 and F2) were extracted from each vowel token. Results showed that all vowel categories in the patients with PSD were produced with more variability than in the healthy speakers. Great overlaps between vowel categories and reduced vowel space were observed in the patients. The magnitude of the vowel dispersion and overlap between vowel categories increased as a function of the severity of the disorder. The deviations of the vowel acoustic features in the patients in comparison to the healthy speakers may provide guidance for clinical rehabilitation to improve the speech intelligibility of patients with PSD.

A Survey of Speech-Language-Hearing Therapists' Career Situation and Challenges in Mainland China.

AIMS: The aim of this survey was to investigate the background of speech-language pathologists and their training needs to provide a profile of the current state of the profession in Mainland China. METHODS: A survey was conducted of 293 speech-language therapists. The questionnaire used asked questions related to their career background and had a 24-item ranking scale covering almost all of the common speech-language-hearing disorders. A summary of the raw data was constructed by calculating the average ranking score for each answer choice in order to determine the academic training needs with the highest preference among the respondents. RESULTS: The majority of respondents were female, <35 years old and with a total service time of <5 years. More than three quarters of the training needs with the highest preference among the 24 items involved basic-level knowledge of common speech-language-hearing disorders, such as diagnosis, assessment and conventional treatment, but seldom specific advanced technology or current progress. CONCLUSION: The results revealed that speech-language therapists in Mainland China tend to be young, with little total working experience and at the first stage of their career. This may be due to the lack of systematic educational programs and national certification systems for speech-language therapists.